1,2-Benzenediol, 4-(6,7-dimethyl-2-quinoxalinyl)-
Tyrphostin AG1433
CAS: 168835-90-3
Molecular Formula: C16H14N2O2
1,2-Benzenediol, 4-(6,7-dimethyl-2-quinoxalinyl)- - Names and Identifiers
| Name | Tyrphostin AG1433 |
| Synonyms | Tyrphostin AG1433 1,2-Benzenediol, 4-(6,7-dimethyl-2-quinoxalinyl)- |
| CAS | 168835-90-3 |
1,2-Benzenediol, 4-(6,7-dimethyl-2-quinoxalinyl)- - Physico-chemical Properties
| Molecular Formula | C16H14N2O2 |
| Molar Mass | 266.29 |
| In vivo study | Chorion allantoic membrane (CAM) assays are used to determine the effects of the Flk-i inhibitors on angiogenesis. Tyrphostin AG1433 (SU1433) is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day-old chicken embryos. Tyrphostin AG1433 prevents the formation of new yessels under the pellets. |
1,2-Benzenediol, 4-(6,7-dimethyl-2-quinoxalinyl)- - References
| biological activity | Tyrphostin AG1433 (SU1433) is a tyrosine kinase inhibitor. Tyrphostin AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with an IC50 of 5.0 μm and 9.3 μm, respectively. Tyrphostin AG1433 prevents angiogenesis. |
| Cell Line: | GB8B cells |
| Concentration: | 0.1 μM, 1 μM, 5 μM, 10 μM, 20 μM, 30 μM, 50 μM, 60 μM, 100 μM |
| Incubation Time: | 72 hours |
| Result: | Induced significant cell death in GB8B cells in a concentration-dependent manner. |
Last Update：2024-04-09 21:54:55
